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邵红伟

2016/11/16 11:55:58人浏览

邵红伟,1976-,


教育经历:

2002.9-2005.12,中山大学(生物化学与分子生物学专业),理学博士

1999.9-2002.6,河南师范大学(动物学专业,分子遗传方向),理学硕士

1995.9-1999.6,河南师范大学(生物教育专业),理学学士

研究方向:

抗肿瘤TCR-T;TCR分子的结构改造及功能研究;T细胞亚群的免疫调节及与肿瘤细胞的相互作用研究;基因编辑技术与免疫细胞功能研究;药用植物microRNA的筛选与评价;肿瘤相关启动子调控自杀基因的抗肿瘤活性研究。


科研项目:

1)国家自然科学基金项目,结构域替换对TCR分子表达、组装和识别能力的影响(31100664),(主持)

2)广东省自然科学基金项目,抗原特异性TCR 基因修饰Th17 细胞对于打破肿瘤诱导免疫耐受的影响(2014A030313586),(主持)

3)广东省科技计划项目,靶向PD-1和CTLA-4基因CRISPR-Cas重组腺病毒的研发及提高免疫细胞抗肿瘤活性的研究(2016A020215157),(主持)

4)肿瘤特异性TCR基因的恒定区分子改构与功能研究(10151022401000024),广东省自然科学基金。(主持)

5)外源TCR基因在受体T细胞中的组装及T细胞的免疫耐受研究(2008342),广东高校优秀青年创新人才培育项目。(主持)

6)TCR基因转染影响PBMC肿瘤识别能力的分子机制研究(43555014),广东药学院博士启动基金。(主持)

7)广东省重点实验室建设项目(粤科财字[2012]125号)广东省生物技术候选药物研究重点实验室,(副主任)

8)“重大新药创制”科技重大专项“十一五”计划(2009ZX09103-708)特异性抗肝癌TCR基因药物的研究,(排名3)

10)国家自然科学基金青年基金(31400149)纤毛杆影响嵌合型腺病毒感染T淋巴细胞效率的机制研究,(排名4)


发表文章:

[1]Hongwei Shao, Yanmei Lin, Teng Wang, Yusheng Ou, Han Shen, Changli Tao, Fenglin Wu, Wenfeng Zhang, Huaben Bo, Hui Wang, Shulin Huang. Identification of peptide-specific TCR genes by in vitro peptide stimulation and CDR3 length polymorphism analysis. Cancer Lett. 2015, 363(1):83-91. 

[2]Hongwei Shao, Yusheng Ou, Teng Wang, Han Shen, Fenglin Wu, Wenfeng Zhang, Changli Tao, Yin Yuan, Huaben Bo, Hui Wang, Shulin Huang. Differences in TCR-Vβ repertoire and effector phenotype between tumor infiltrating lymphocytes and peripheral blood lymphocytes increase with age. Plos ONE, 2014, 9(7):e102327. 

[3]Shao H, Zhang W, Hu Q, Wu F, Shen H. Huang S. TCR mispairing in genetically modified T cells was detected by fluorescence resonance energy transfer. Mol Biol Rep. 2010, 37(8):3951-3956. 

[4]Shao H, Lan D, Duan Z, Liu Z, Min J, Zhang L, Huang J, Su J, Chen S, Xu A. Upregulation of Mitochondrial Gene Expression in PBMC from Convalescent SARS Patients. J Clin Immunol. 2006, 26(6):546-554.

[5]Wenfeng zhang, hongwei shao, fenglin wu, xie xin, zhuming li, huaben bo, han shen, teng wang, and shulin huang. Influence of cell physiological state on gene delivery to T lymphocytes by chimeric adenovirus Ad5F35. Scientific Reports, 2016, 6, 22688. (co-author)

[6]Tao C, Shao H, Yuan Y, Wang H, Zhang W, Zheng W, Ma W, Huang S. Imaging T-cell receptor combined CD3ζ reveals improving expression and pairing in living cells. International Journal of Molecular Medicine, 2014, 34(3):849-55.(co-author)

[7]Shen H, Shao HW, Chen XH, Wu FL, Wang H, Huang ZL, Shen J, Wang T, Zhang WF, Huang SL. Identification of a novel HLA-A2-restricted mutated Survivin epitope and induction of specific anti-HCC CTLs that could effectively cross-recognize wild-type Survivin antigen. Cancer Immunol Immunother. 2013, 62(2):393-403. 

[8]Wu F, Zhang W, Shao H, Bo H, Shen H, Li J, Liu Y, Wang T, Ma W, Huang S. Human effector T cells derived from central memory cells rather than CD8(+)T cells modified by tumor-specific TCR gene transfer possess superior traits for adoptive immunotherapy. Cancer Lett. 2013, 339(2):195-207

[9]Zhang WF, Wu FL, Shao HW, Wang T, Huang XT, Li WL, Shen H, Huang SL. Chimeric adenoviral vector Ad5F35L containing the Ad5 natural long-shaft exhibits efficient gene transfer into human T lymphocytes. J Virol Methods. 2013, 194(1-2):52-59. 

[10]Yuan Y, Lu X, Tao CL, Chen X, Shao HW, Huang SL. Forced expression of indoleamine-2,3-dioxygenase in human umbilical cord-derived mesenchymal stem cells abolishes their anti-apoptotic effect on leukemia cell lines in vitro. In Vitro Cell Dev Biol Anim. 2013, 49(10):752-8.

[11]Yin Yuan, Xin Lu, Xuan Chen, Hongwei Shao, Shulin Huang. Jagged1 contributes to the drug resistance of Jurkat cells in contact with human umbilical cord‑derived mesenchymal stem cells. Oncol Lett. 2013, 6(4):1000-1006.

[12]Lan D, Huang G, Shao H, Zhang L, Ma L, Chen S, Xu A. An improved nonchromatographic method for the purification of recombinant proteins using elastin-like polypeptide-tagged proteases. Anal Biochem. 2011, 415(2):200-2. 

[13]Bo H, Chen J, Liang T, Li S, Shao H, Huang S. Chromatographic purification of adenoviral vectors on anion-exchange resins. Eur J Pharm Sci. 2015, 67:119-25. 

[14]Bo H, Wang J, Chen Q, Shen H, Wu F, Shao H, Huang S. Using a single hydrophobic-interaction chromatography to purify pharmaceutical-grade supercoiled plasmid DNA from other isoforms. Pharm Biol. 2013, 51(1):42-8.


专利:

[1]发明专利“Survivin启动子调控CD基因的重组腺病毒载体构建及其应用”,专利号:ZL201310391654.7

[2]发明专利“人TCRβ7.1_H3F7基因及其筛选方法和应用”,专利号:ZL200710028742.5

[3]发明专利“超螺旋质粒分离纯化工艺”,专利号:ZL200710028389.0


获奖:

[1] 2016年广州市科学技术进步奖二等奖,特异性抗肿瘤TCR基因候选药物的研究

[2] 第六届广东省高等教育教学成果奖二等奖,生物医药类专业创新人才培养模式的实践与探索

[3] 第十二届全国医药卫生青年科技论坛三等奖(基础),Differences in TCR-Vβ repertoire and effector phenotype between tumor infiltrating lymphocytes and peripheral blood lymphocytes increase with age 

[4] 广东药科大学第九次教学成果奖特等奖,生物医药类专业创新人才培养实验区的构建

[5] 指导学生获得第十届“挑战杯”广东大学生课外科技活动竞赛一等奖

[6] 指导学生获得第十一届“挑战杯”全国大学生课外科技活动竞赛三等奖


学术兼职:

中国医药质量管理协会细胞治疗质量控制与研究专业委员会常务委员,中国研究型医院学会细胞研究与治疗专业委员会委员,澳门生命与环境科学技术协会理事,中国医药生物技术协会会员,中国免疫学会会员; Oncotarget、International Journal of Oncology、PLoS ONE、中国医药生物技术、广东药科大学学报、集美大学学报等期刊审稿人。